Nano SiO2 catalyzed synthesis of Imidazo[1,2-a]pyridines

Nano SiO2 catalyzed synthesis of Imidazo[1,2-a]pyridines

Tejeswararao Dharmana Koteswara Rao Kola Nagamani Naidu Bonnada 

GMR Institute of Technology, Rajam, Andhra Pradesh, PIN 532127, India

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 A facile microwave assisted reaction of phenacyl bromide and 2-amino pyridine is catalyzed by Nano SiO2 under solvent free conditions to give corresponding Imidazo[1,2-a]pyridines in good yields. Reactions proceed with high efficiency and good functional group tolerance. This approach provides a useful protocol for the preparation of highly substituted Imidazo[1,2-a]pyridine derivatives


nano SiO2, microwave irradiation, Imidazo[1,2-a]pyridines, phenacyl bromide

1. Introduction
2. Materials and methods
3. Results and discussion
4. Conclusion

We are highly thankful to GMR Institute of Technology, Rajam for financial assistance


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