Insilico Studies of Tau-protein Kinase

Insilico Studies of Tau-protein Kinase

Ranganadha R.A.

Department of Biotechnology, VFSTR University, Vadlamudi, Guntur 522213, Andhrapradesh, India

Corresponding Author Email:
18 September 2018
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26 November 2018
| | Citation



One of the most common types of dementia is Alzheimer’s disease and it is related to tangles and plaques in the brain. Memory loss and symptoms like confusion and difficulty with remembering things indicate the onset of the disease. The symptoms are signs given by body to indicate brain cells death. In brain there are 100 billion nerve cells commonly known as neurons. Networks are formed when communication takes place between these nerve cells. Alzheimer’s disease is very much similar to other forms of dementia as with time more and more brain cells die. Tau protein kinase enzyme catalyzes the transferring of the phosphate group to the oxygen side chains of the serine / threonine residues. Tau protein is one of the vital proteins that are present in the central nervous systems it helps to stabilize the neurons and microtubules. One of the main features of Alzheimer’s is abundantly found neurofibrillary lesions that are made from Tau-protein that has been hyperphoshorylated. For stabilizing microtubules Tau-protein interact with tubulin. Auto assemblage of tangles with in the straight filaments and helical fragments takes place due to excessive phosphorylation of tau-protein. Dementia is caused to due malfunctioning of tau-protein that further causes Alzheimer’s disease.


Alzheimer, tau protein, homology modeling, SWISS MODEL

1. Introduction
2. Methodology
3. Results and Discussion
4. Conclusion

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