Nano SiO2 catalyzed synthesis of Imidazo[1,2-a]pyridines

Nano SiO2 catalyzed synthesis of Imidazo[1,2-a]pyridines

Tejeswararao Dharmana Koteswara Rao Kola Nagamani Naidu Bonnada 

GMR Institute of Technology, Rajam, Andhra Pradesh, PIN 532127, India

Corresponding Author Email: 
tejeswararao.d@gmrit.org
Page: 
547-553
|
DOI: 
https://doi.org/10.3166/ACSM.42.547-553
Received: 
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Accepted: 
|
Published: 
31 December 2018
| Citation

OPEN ACCESS

Abstract: 

 A facile microwave assisted reaction of phenacyl bromide and 2-amino pyridine is catalyzed by Nano SiO2 under solvent free conditions to give corresponding Imidazo[1,2-a]pyridines in good yields. Reactions proceed with high efficiency and good functional group tolerance. This approach provides a useful protocol for the preparation of highly substituted Imidazo[1,2-a]pyridine derivatives

Keywords: 

nano SiO2, microwave irradiation, Imidazo[1,2-a]pyridines, phenacyl bromide

1. Introduction
2. Materials and methods
3. Results and discussion
4. Conclusion
Acknowledgements

We are highly thankful to GMR Institute of Technology, Rajam for financial assistance

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