3D Printing in Biomedical Applications

3D Printing in Biomedical Applications
Mepco Schlenk Engineering College (Autonomous), Sivakasi 626005, India

Corresponding Author Email: 
venkatramanb@mepcoeng.ac.in
Page: 
22-38
|
DOI: 
https://doi.org/10.18280/ti-ijes.630104
Received: 
28 January 2019
|
Accepted: 
15 March 2019
|
Published: 
31 March 2019
| Citation

OPEN ACCESS

Abstract: 

This study deals with the 3D Bio-Printing technology, a type of additive manufacturing in which the 3D object is imitated to be visual within the allocated period of time interval that resembles similar in considered aspects of real world objects like kidney, bones and many other body parts. The material used includes the powders of polymer mass that are solidified by directional laser heating. While talking about Bio-Printing, the material used are living tissues, calcium source, vascular tissue, placental fluid, embryonic stem cell etc., and the entire organ is regenerated from the tissue, which is being printed in the enzymatic incubation medium. The regenerated organ is similar to the patient’s organ. The information of the patient's organ get read from many scanning devices. The making of organ is controlled by the speed of filling tissue, temperature at which the process is carried out, bonding agent to bond the tissues together, incubation medium, type of tissue, body immunity, stem cell growing phenomenon, filler head movement respective to all the axes, slicing path, etc., The produced artificial organ (human bone, human kidneys, bladder, etc.,) can be replaced with the defected organ. Thus, the controlled action of all the parameters can lead to the organic replacement of the birth similar organs.

Keywords: 

enzymatic incubation medium, birth similar organs, 3D bio-printing, additive manufacturing, embryonic stem cell, placental fluid

1. Introduction
2. Principle and Factors to be Considered in 3D Bio-printing Process
3. 3D Skin Printing
4. Various Sections of 3D Printed Kidney
5. Kidney Model
6. The Process of Filtering the Blood
7. Parameters for Simulation Using Matlab Programming
8. Comparison of Parameters
9. Applications
10. Conclusion
  References

[1]    Hasenbank MS, Edwards T, Fu E, Garzon R, Kosar TF, Look M, Mashadi-Hossein A, Yager P. (2008). Demonstration of multi-analyte patterning using piezoelectric inkjet printing of multiple layers. Analytica Chimica Acta 611(1): 80-88. https://doi.org/10.1016/j.aca.2008.01.048

[2]    Allain LR, Stratis-Cullum DN, Vo-Dinh T. (2004). Investigation of microfabrication of biological sample arrays using piezoelectric and bubble-jet printing technologies. Analytica Chimica Acta 518(1-2): 77-85. https://doi.org/10.1016/j.aca.2004.04.065

[3]    Whitesides. (1991). Molecular self-assembly and nano chemistry: A chemical strategy for the synthesis of nanostructures. Science 254(5036): 1312-1319. https://doi.org/10.1126/science.1962191

[4]    Loninia L, Accoto D, Petroni S, Guglielmelli E. (2008). Dispensing an enzyme-conjugated solution into an ELISA plate by adapting ink-jet printers. Journal of Biochemical and Biophysical Methods 70(6): 1180-1184. https://doi.org/10.1016/j.jbbm.2007.05.003

[5]    Schubert C, Van Langeveld MC, Donoso LA. (2014). Innovations in 3D printing: a 3D overview from optics to organs. Br J Ophthalmol 98(2): 159-161.

[6]    Ursan I, Chiu L, Pierce A. (2013). Three-dimensional drug printing: A structured review. Journal of the American Pharmacists Association 53(2): 136-144. https://doi.org/10.1331/JAPhA.2013.12217

[7]    Mertz L. (2013). Dream it, design it, print it in 3-D: what can 3-D printing do for you. IEEE Pulse 4(6): 15-21. https://doi.org/10.1109/MPUL.2013.2279616

[8]    Gross BC, Erkal JL, Lockwood SY. (2014). Evaluation of 3D printing and its potential impact on biotechnology and the chemical sciences. Analytical Chemistry 86(7): 3240-3253. https://doi.org/10.1021/ac403397r

[9]    Ozbolat IT, Yu Y. (2013). Bioprinting toward organ fabrication: Challenges and future trends. IEEE Transactions on Biomedical Engineering 60(3): 691-699. https://doi.org/10.1109/TBME.2013.2243912

[10]  Bertassoni LE, Cecconi M, Manoharan V, Nikkhah M, Hjortnaes J, Cristino AL, Barabaschi G, Demarchi D, Dokmeci MR, Yang Y, Khademhosseini A. (2014). Hydrogel bioprinted microchannel networks for vascularization of tissue engineering constructs. Lab on a Chip. 14(13): 2202-11. https://doi.org/10.1039/c4lc00030g

[11]    Lipson H. (2013). New world of 3-D printing offers completely new ways of thinking. IEEE Pulse 4(6): 12-14. https://doi.org/10.1109/MPUL.2013.2279615

[12]   Khaled SA, Burley JC, Alexander MR, Roberts CJ. (2014). Desktop 3D printing of controlled release pharmaceutical bilayer tablets. International Journal of Pharmaceutics 461(1-2): 105-111. https://doi.org/10.1016/j.ijpharm.2013.11.021